Marek Šoltys – Diploma thesis summary

Synthesis of metallocorroles and their application through nanocarriers

This work consists of preparation of 500-600 nm large hollow porous silica particles and their composites with iron oxide, synthesis of novel gold corrole and sapphyrin and study of possible mechanisms of encapsulation of both water soluble and water insoluble corroles into the silica particles. The prepared silica particles could also find an application as carriers for other active substances in medical, environmental or industry use. Both corroles and sapphyrins are known to be phosphorescent, which opens up possibilities in phosphorescent nanomarker applications and gold corroles were found to be cytotoxic which could lead to interesting medical applications. An example of such an application was demonstrated. The prepared particles and the newly discovered compounds were characterized using broad range of analytical methods available.