Lucie Vidlářová, Jarmila Zbytovská, Jaroslav Hanuš, František Štěpánek
Lipid-based nanoformulations such as solid lipid nanoparticles or liposomes have the potential to encapsulate pharmaceutical or cosmetic actives and enhance their delivery to the skin.
The aim of this study is to design dermal drug delivery systems and to improve our understanding of the formulation-structure-function relationships. Currently we investigate the skin penetration profile of a model lipophilic dye delivered by lipid-based nanoformulations using fluorescence microscopy. The obtained images are further analyzed by novel statistically robust quantitative image analysis methods.