Lucie Vidlářová, Jarmila Zbytovská, Jaroslav Hanuš, František Štěpánek
Lipid-based nanoformulations such as solid lipid nanoparticles or liposomes have the potential to encapsulate pharmaceutical or cosmetic actives and enhance their delivery to the skin.
The aim of this study is to design dermal drug delivery systems and to improve our understanding of the formulation-structure-function relationships. Currently we investigate the skin penetration profile of a model lipophilic dye delivered by lipid-based nanoformulations using fluorescence microscopy. The obtained images are further analyzed by novel statistically robust quantitative image analysis methods.
Cross-sectional fluorescent image of porcine skin treated with A) dye simply dissolved in oil and B) dye encapsulated to lipid nanoparticles.
Publications
- Zbytovská J., Gallusová J., Vidlářová L., Procházková K, Šimek J., Štěpánek F., “Physical compatibility of Propofol-Sufentanil mixtures”, Anesthesia & Analgesia, 124, 776-781 (2017)
- Vidlářová L., Hanuš J., Veselý M., Ulbrich P., Štěpánek F., Zbytovská J., “Effect of lipid nanoparticle formulations on skin delivery of a lipophilic substance”, Eur. J. Pharm. Biopharm. 108, 289-296 (2016)
- Vidlářová L., Romero G.B., Hanuš J., Štěpánek F., Müller R.H., “Nanocrystals for dermal penetration enhancement – effect of concentration and underlying mechanisms using curcumin as model”, Eur. J. Pharm. Biopharm. 104, 216-225 (2016)