Particle & material analysers

Equipment

Microtrac NANO-flex – 180° DLS Size analyser

• NANOflex 180suitable for concentrations up to 40% vol. • Suitable for broad size distributions • Particle size range of 0.8 nm to 6500 nm
Equipment

Malvern NanoSight NS300 - nanoparticle tracking system

• Rapid and automated size distribution and concentration analysis • Particle size range of 10 nm to 2000 nm • Enhanced fluorescence detection capability
Equipment

Malvern Zetasizer Nano-ZS

• Dynamic Light Scattering, Static Light Scattering • Particle size range 0.6 nm - 6 μm • Zeta potential - in aqueous and non-aqueous dispersions
Equipment

Horiba Partica LA-950 S2 particle size analyser

• Dual laser source of 650 nm and 405 nm • Particle size range of 10 nm to 5000 μm • Three measuring cells: dry, wet, and fraction cell
Equipment

Brookfield CT3 Texture Analyser

• Both compression and tensile testing • Six built-in test modes, up to 50 kg • A variety of detachable testing probes
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Microtrac MRB CAMSIZER X2

• Particle size and particle shape analysis from 0.8 μm to 8 mm with Dynamic Image Analysis (ISO 13322-2) • Fully comparable to sieve analysis and laser diffraction results • Ultra-strong LEDs and high-resolution cameras for the clearest results

Imaging instruments & microscopes

Equipment

Bruker ICON - MRI desktop system

• Compact and easy-to-use cryogen-free high-performance MRI desktop system • MRI scanner for small rodents like rats and mice
Equipment

FTIR system

• Nicolet iN10 infrared microscope • Nicolet iZ10 FTIR module with ATR accessory
Equipment

Laser Scanning Confocal Microscope

• Olympus Fluoview FV1000 confocal system • Olympus IX81 inverted microscope base
Equipment

Jeol JCM-5700 Scanning Electron Microscope

• High and low vacuum mode • Secondary and backscatter electron imaging • Spatial resolution up to 5 nm
Equipment

Sirius Surface Dissolution UV Imager

• SiriusSDIreal-time UV videos of the dissolution process • Static or under flow • 2D array of pixels
Equipment

SkyScan Micro-CT SEM attachment

• X-ray microtomography in SEM • Spatial resolution of up to 800 nm • 3D volume visualisation and analysis
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Phenokey Micro-CT X-Ray

•Table top size • Resulution up to 4 μm per pixel • Rotational stage for 3D imaging

Particle production instruments

Equipment

Mini Spray Dryer B-290 with Inert Loop B-295

• Produce dry particles in range 1 – 25 μm • Suitable also for heat sensitive materials (short residence time) • Possibility to use organic solvents (in combinations with Inert Loop)
Equipment

Encapsulator B-395 Pro

• Device for controlled encapsulation of (bio)materials • Monodisperse particle production • Enables completely sterile environment, if required
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Fluidbed Mini-Glatt / Midi-Glatt

• batch-executed fluidized bed processes for testing granulation, drying and coating processes • batch sizes of 2.5 to 1,300 grams • Flexible retrofitting if needed.
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Tablet Press Natoli NP-RD10A

• Independent control of both tablet thickness, hardness, and weight. • Sensitive enough to yield critical data from minimal amounts of APIs, yet robust enough for hands-on research
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Hosokawa Micron B.V. Mini Cyclomix

• Exchangeable product bowls, volumes 0.1, 1 or 2 litres • Accurate temperature control with jacketed vessels • Sterile and CIP/SIP execution possible

Analytical instruments

Equipment

Agilent Cary Eclipse Fluorescence Spectrophotometer

• Fluorescence, phosphorescence, chemi/bio-luminescence • 4-cell thermostatted sample holder • 2 temperature probes
Equipment

ThermoScientific Evolution 220 UV-Visible Spectrophotometer

• Double beam • Single Xenon flash lamp with 190-1100 nm range • Smart 8-Cell Peltier system for temperature control
Equipment

PION µDISS Profiler - Miniaturized in situ Concentration Monitoring

• Small Volume Dissolution (2-20 mL) • In situ UV Monitoring (200 -720 nm) • Individually Controlled 8 Channel Stirring • Interchangeable pathlehgth probe tips
Equipment

Specord 205 BU uv-vis spectrophotometer

• Double beam • Spectral range 190-1100 nm, slit width 1.4 nm • Turbid samples
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Dissolution apparatus with custom made autosampler

• Six Standard or mini-padle dissolution vessels • Custom made auto-sampler • Online UV-VIS measurement
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HPLC Agilent 1100

• DAD detector • binary pump • Support for variety of columns

Other instruments

Equipment

RF induction heating

• 32/400 and 64/900 CEIA PowerCube RF generators • 3 different water cooled copper coils • Optical thermometer
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ZMORPH FAB 3D Printer

• Multitool 3D Printer • Thick Paste Extruder • single or dual extruder • professional CNC worktable
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Prusa i3 MK3+ a Prusa Mini

• Variety of supported materials • Multi-extrusion • Fast and reliable high quality prints

Smaller Equipment

  • Olympus stereo microscope and inverted microscope with CCD cameras
  • Precision balances
  • Vacuum drying oven
  • Ultrasound generator
  • Colloid mill
  • Vibration ball mill
  • Drop-on-demand print head
  • Centrifuge
  • Spin coater
  • Demineralised water generator
  • Freeze dryer
  • Rotary evaporator

Laboratory

Chemical robotics laboratory was established in 2008. In the beginning we operated only from two refurbished, fully air-conditioned laboratories of approximately 90 m² total floor area in the room B308 in the building B of University of Chemistry and Technology Prague. The smaller “wet” chemistry lab was adjacent to a larger “clean” physical and characterisation lab (see laboratory photogallery 2008, 2009). In 2010 we got an office room next to this lab (room B307). The head of the group prof. Stepanek is sitting in the room BS64. In 2012 we got the room BS67 and repurposed it to serve as a clean laboratory for biological experiments. In 2013 we have acquired the MRI device and with it the room BS52 which was reconstructed and now it also houses our 3D printers. The latest addition to the CHOBOTIX groups room collection is the room BS62, reconstructed in 2015, where you can find a fully equipped lab with a large walk-in hood and a dark room. It is adjoined by an office, a small meeting room and a small kitchen.